The role of thrombopoietin signalling in JAK2V617F-positive myeloproliferative neoplasms

Thrombopoietin (TPO) is the primary regulator of megakaryocyte development, regulating proliferation and differentiation in addition to the number of circulating platelets through binding to and stimulation of the cell surface receptor MPL. Activating mutations in MPL constitutively stimulate downst...

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Bibliographic Details
Main Author: Sangkhae, Veena
Other Authors: Hitchcock, Ian
Published: University of York 2015
Subjects:
570
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665050