Involvement of alternative splicing of the insulin and androgen receptors in prostate cancer : role of the insulin like growth factor axis
The insulin receptor (IR) exists as two isoforms IR-A and IR-B, due to alternative splicing of exon 11. It is reported that IR-A is over-expressed in a number of cancers. This PhD aimed to assess the ratio of IR isoforms in prostate cancer cell lines and to manipulate the IR isoform ratio in an atte...
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University of Bristol
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665464 |