Biophysical and structural characterisation of protein-protein interactions, HIF-1α/p300 and eIF4E/eIF4G to inform inhibitor rational design
Protein-protein interactions (PPIs) are an important class of therapeutic target, however due to their large interaction interface they are considered difficult to inhibit. The two PPIs of interest in this thesis are the HIF-1α (hypoxia inducible factor-1α)/p300 and eIF4E (eukaryotic initiation fact...
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University of Leeds
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669609 |