The role of conserved residues in Lactobacillus casei dihydrofolate reductase
Mutants of three conserved residues in Dihydrofolate reductase (DHFR) from Lactobacillus casei have been studied to assess their roles in ligand binding and catalysis. Aspartate26 has been widely postulated to be the source of the proton in the reaction catalysed by DHFR; this was probed by the Aspa...
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University of Leicester
1994
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674346 |