Regulation of Bcl-X splicing by G-quadruplexes enables regulation by G-quadruplex ligands to favour apoptosis
The Bcl-2 family of proteins are the primary regulators of the intrinsic apoptotic pathway, with anti-apoptotic members up regulated in cancer. Bcl-X is of particular interest, as it can be alternatively spliced to yield antagonistic proteins, the proapoptotic Bcl-XS and the anti-apoptotic Bcl-XL. H...
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University of Leicester
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674538 |