Using mouse models to learn about mitochrondial DNA point mutations in ageing and disease
Mitochondrial DNA (mtDNA) point mutations clonally expand and result in focal respiratory chain deficiency in tissues of patients with mitochondrial disease and to a lesser extent in normal human ageing. The consequences of mtDNA point mutations upon cellular processes and the mechanisms involved in...
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University of Newcastle upon Tyne
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674809 |