Studies of VAPB and TDP-43 in neurodegeneration
The aggregation of TDP-43 in the cytoplasm of motor neurons is a hallmark pathology in many sporadic and familial cases of amyotrophic lateral sclerosis (ALS). A mutation in the protein VAPB at proline 56 (VAPB P56S) was identified as the causative mutation for ALS type 8 and transgenic mice express...
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King's College London (University of London)
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677156 |