The potential therapeutic benefit of targeting S-phase kinase-associated protein 2 (SKP2) in neuroblastoma
S-phase kinase-associated protein 2 (SKP2) is the substrate recognition subunit of the SCF E3 ubiquitin ligase complex which monitors the G1/S transition of the cell cycle. SKP2 is a positive regulator of cell cycle progression targeting tumour suppressor proteins for degradation, primarily the cycl...
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University of Newcastle upon Tyne
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680320 |