Transcriptional role of BRCA1 in the DNA damage response
BRCA1 plays a key role in several cellular pathways, including DNA damage response, transcriptional regulation and DNA double strand break repair. However, BRCA1 mutation carriers primarily develop breast and ovarian cancers, both of which are estrogen-regulated tissues. Estrogen exposure is a well-...
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Queen's University Belfast
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680886 |