TRPM2 ion channel trafficking and its role in mitochondrial fragmentation and cell death

Mitochondria play a central role in oxidative stress-induced cell death. By increasing the production of reactive oxygen species, such as H2O2, oxidative stress causes mitochondrial fragmentation and apoptosis. It was hypothesised that Transient Receptor Potential Melastatin 2 (TRPM2) channels play...

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Bibliographic Details
Main Author: Abuarab, Nada Khaled S.
Other Authors: Sivaprasadarao, Asipu
Published: University of Leeds 2015
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682277