Structural and functional characterisation of Dickkopf4 (Dkk4), a key inhibitor of Wnt signalling

A growing weight of experimental evidence indicates that all four secreted protein members of the cysteine-rich Dkk family, Dkk1, Dkk2, Dkk3 and Dkk4, can act as inhibitors of the Wnt pathway. To date, no structural and little functional information has been reported for Dkk4, which has been the foc...

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Bibliographic Details
Main Author: Barkell, Alice Mary
Other Authors: Carr, Mark ; Robinson, Martyn
Published: University of Leicester 2013
Subjects:
572
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682375