Genome-wide analysis of topoisomerase removal after campothecin treatment in the context of replication and transcription
Camptothecin (CPT) and its derivatives (e.g. Irinotecan) are commonly used anticancer drugs which increase the half-life of topoisomerase I (Top1) cleavage complexes (Top1cc) during the Top1 catalytic cycle. Even in the presence of CPT Top1 will eventually remove itself by resuming its catalytic cyc...
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Bangor University
2015
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683527 |