In vitro and in vivo characterisation of the mechanisms involved in opioid-induced tolerance

Opioid analgesics are the leading class of prescription drugs that cause unintentional overdose deaths via respiratory depression. Poly-drug use is a common cause of death, with ethanol detected in approx.. 50% of heroin-related cases. Tolerance can be reversed by low concentrations of ethanol in lo...

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Bibliographic Details
Main Author: Withey, Sarah Louise
Published: University of Bristol 2015
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684743