Mechanisms of GABAA and glycine receptor analgesia in the spinal dorsal horn : in vitro models as translational platforms for drug discovery

Available analgesics do not always provide adequate pain relief and are often associated with a significant side-effect profile. Following reports of a loss of inhibitory signalling in the spinal dorsal horn (DH) network in persistent pain conditions, γ-amino butyric acid type A (GABAA) and glycine...

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Bibliographic Details
Main Author: Griffiths, Natalie Helen
Other Authors: King, Anne E. ; Nickolls, Sarah
Published: University of Leeds 2015
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685235