Metabolic status modulates tumour cell sensitivity to apoptotic stimuli
Chronic lymphocytic leukaemia and mantle cell lymphoma (MCL) are resistant to TNF Related Apoptosis Inducing Ligand (TRAIL), which induces apoptosis via DISC-mediated activation of caspase-8, cleavage of Bid and activation of the mitochondrial cell death pathway. Cancer cells preferentially utilise...
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University of Leicester
2016
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686563 |