A tool-kit for in-process determination and control of structural and conformational authenticity of complex biopharmaceuticals
The work presented here focuses on a Chinese hamster ovary cell line producing monoclonal IgG. A key challenge in the production of mAbs is to produce a consistent glycoform profile between batches, since glycosylation can impact efficacy. This work examines the effect of time of harvest and means o...
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University College London (University of London)
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686675 |