The molecular control of beta cell function by insulin and hypoxia cellular signalling pathways
This thesis reports the investigation of the role of the insulin receptor substrate 2 (Irs2) and von Hippel-Lindau (Vhl) genes in B-cell function, using the cre-loxP system to delete these genes in the pancreas of mice. Pancreatic 8-cells sense and respond to the metabolic status of the body via cel...
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University College London (University of London)
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.689441 |