Synthesis of bioactive fluorinated bile acid analogues and investigating the influence of (deoxo)fluorination on alkanol and carbohydrate lipophilicity by a new logP determination method
Since the identification of bile acids as natural ligands for FXR and TGR5 receptors, huge interest has arisen in this field, including the synthesis of semi-synthetic bile acid derivatives to increase binding potency and selectivity. Fluorine introduction is an attractive strategy in drug design an...
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University of Southampton
2016
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.690315 |