Development of in-vitro human and rat proximal tubule cell models as a platform for drug transporter and drug-drug interaction studies
The kidney plays a key role in the systemic clearance of new molecular entities (NMEs). Approximately 32% of drugs exhibit significant renal elimination. It is estimated that nephrotoxicity accounts for 8 % of pre-clinical and 9% of clincal safety failures in drug development. Current pre-clinical m...
| Main Author: | |
|---|---|
| Published: |
University of Newcastle upon Tyne
2015
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.692640 |