Investigating the mechanism and energy coupling of DNA gyrase

DNA gyrase is the bacterial type II topoisom erase w hich couples the free energy o f ATP hydrolysis to the introduction of negative supercoils into DNA. The active enzym is composed of two GyrA and two GyrB subunits forming an A2B2 complex. The specific supercoiling activity of GyrB was found to be...

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Bibliographic Details
Main Author: Smith, Clare Victoria
Published: University of Leicester 1998
Subjects:
572
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696426