Genotoxicity of tamoxifen and structural analogues of tamoxifen : studies on the activation of tamoxifen by cytochrome P450s and peroxidase
This thesis investigates the activation of tamoxifen and structural analogues of tamoxifen by cytochrome P450s and peroxidase. In human lymphoblastoma derived cell lines expressing cDNAs for different human CYP-isoforms, tamoxifen, toremifene and 4-hydroxytamoxifen were clastogenic. Micronucleus for...
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University of Leicester
1999
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696581 |