The ATP-operated clamp of human DNA topoisomerase IIα
The type II DNA topoisomerases operate via a complex multistep mechanism: one segment of DNA (the T segment) is captured by the N-terminal domains and directed through a transient break in another DNA segment held by the core of the enzyme (the G segment). In most reactions of type II enzymes, this...
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University of Leicester
2001
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696935 |