Control of IFN-γ response via autocrine activation of the C5a complement receptors and the NLRP3 inflammasome within human T lymphocytes
IL-1β is a pro-inflammatory cytokine critical for the protection against pathogens. The NLRP3 inflammasome mediates the maturation of IL-1β, however uncontrolled inflammasome activity contributes to the development of several diseases with strong impact on public health. The complement system is inv...
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King's College London (University of London)
2016
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.700795 |