Developing novel transgenic reporters to study Lowe syndrome in zebrafish
Lowe syndrome is a rare X linked disorder, characterized by renal, ocular and cerebral defects, caused by mutation in the protein OCRL1. OCRL1 has been implicated in a plethora of cellular functions, and loss of its catalytic conversion of PtdIns(4,5)P2 into PtdIns(4)P is proposed to underly many of...
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University of Manchester
2017
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703016 |