Cellular senescence induced by RUNX1 and its fusion oncoprotein derivatives as a barrier to leukaemogenesis
This thesis explores the ability of RUNX1 and its fusion oncoprotein derivatives to induce senescence-like growth arrest (SLGA) in primary cell cultures. While this phenomenon resembles replicative senescence seen in normal diploid human fibroblasts after extensive passage, it does not involve telom...
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University of Glasgow
2017
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705583 |