Enzymatic synthesis of chemically modified DNA for analytical and diagnostic applications

Functionalised nucleotides have found widespread adoption in applications ranging from genome labelling to disease diagnostics. A popular means of introducing these modifications into nucleic acids is via the copper-catalysed azide-alkyne cycloaddition reaction. However, the toxicity of copper limit...

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Bibliographic Details
Main Author: Ren, Xiaomei
Other Authors: Brown, Tom
Published: University of Oxford 2015
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.712439