The role of R-loops in the pathology of trinucleotide expansion diseases
Friedreich ataxia and fragile X syndrome are among 40 human diseases associated with expansion of repeated DNA sequences. In both disorders repeat expansion leads to gene silencing, the molecular mechanism of which is not well understood. It was proposed that formation of unusual DNA structures such...
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University of Oxford
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.712522 |