PTEN as a therapeutic target for the promotion of cell survival in cell models of amyotrophic lateral sclerosis
Rationale & Hypothesis: ALS is a fatal neurodegenerative disorder for which a GGGGCC hexanucleotide repeat expansion in C9ORF72 has been identified to be the most common genetic cause. Pathologically, ALS is characterised by premature death of motor neurons. The inhibition of Phosphatase and Ten...
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University of Sheffield
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715096 |