The detection and clinical significance of TP53 dysfunction in chronic lymphocytic leukaemia
Standard therapy for patients with chronic lymphocytic leukaemia involves the use of DNA damaging drugs. If the cellular DNA damage response has been compromised then these standard therapies will be ineffective at inducing apoptosis. Central to this response is the protein, p53. Loss of the chromos...
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Bournemouth University
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.720779 |