Development and validation of a next generation sequencing based microsatellite instability assay for routine clinical use
Colorectal cancer (CRC) is the second most common cancer in both men and women. Approximately 3-5% of CRCs show microsatellite instability (MSI) caused by germline defects in mismatch repair genes. In addition, 12% of sporadic CRCs show MSI. Currently, MSI is tested using a fragment analysis based a...
| Main Author: | |
|---|---|
| Published: |
University of Newcastle upon Tyne
2016
|
| Subjects: | |
| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.722373 |