Altered heparan sulfate in ageing and dementia : a potential axis for the dysregulation of BACE-1 in Alzheimer's disease
Alzheimer’s disease (AD) is characterised by amyloid plaques composed of amyloid-beta (Aβ), the cleavage product of the amyloid precursor protein (APP) by the protease beta-secretase (BACE- 1). Heparan sulfate (HS) inhibits BACE-1 and holds potential as a new drug discovery target; in vivo HS may ac...
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University of Liverpool
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.724491 |