The role of p97 cofactors SPRTN and FAF1 in DNA replication

It is well known that cancer cells are loaded with excess proteins. To survive this proteotoxic crisis cancer cells rely heavily on the ubiquitin proteasome system (UPS). Valosin containing protein (VCP) or p97 has recently emerged as a central player of UPS. Moreover, p97 inhibitors were shown to p...

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Bibliographic Details
Main Author: Halder, Swagata
Other Authors: Ramadan, Kristijan
Published: University of Oxford 2016
Subjects:
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730101