The role of the cellular membrane environment in mediating fibrillization and toxicity of islet amyloid polypeptide

Islet amyloid polypeptide (IAPP) is a peptide that is produced by the beta cells in the pancreas. A misfolded, aggregated form of this peptide is associated with Type 2 Diabetes and is found as large brils in pancreata, intimately associated with the islet architecture. The role of these brils is th...

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Bibliographic Details
Main Author: Carmen, Helder
Other Authors: Vaux, David
Published: University of Oxford 2016
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730309