Synthesis and properties of oligonucleotides containing triazole backbone linkages and 2'-modifications for therapeutic applications
Antisense oligonucleotides are short strands of DNA, which bind to their complementary mRNA target to prevent protein translation. Although conceptually appealing, for their practical use as drugs, these oligonucleotides must have better cellular uptake, resistance to enzymatic degradation, and targ...
| Main Author: | |
|---|---|
| Other Authors: | |
| Published: |
University of Oxford
2016
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730453 |