Computational investigation of small-molecule human tissue transglutaminase inhibitors
Human tissue transglutaminase (TG2) catalyses transamidation and deamidation reactions through a nucleophilic cysteine residue (CYS277). TG2 activity was found to increase in celiac disease, cystic fibrosis, neurodegenerative disorders and cancer. For this, TG2 has received much focus as a target fo...
| Main Author: | |
|---|---|
| Published: |
Aston University
2017
|
| Subjects: | |
| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742470 |