Involvement of the lysosomal protein NPC1 in the pathogenesis of Huntington's disease
Huntington's disease is an autosomal dominant inherited neurodegenerative disease, with cognitive, motor and psychiatric defects and no known therapy. Altered lipid metabolism and lysosomal dysfunction have been seen in Huntington's disease (HD), including lysosomal expansion, a key featur...
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Cardiff University
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742844 |