Investigating the role of DNA (cytosine-5)-methyltransferase 1 in mitochondrial DNA methylation
Mitochondrial DNA (mtDNA) that escapes from autophagy-mediated degradation after hemodynamic stress can cause inflammation in the heart by activating TLR9 signalling pathway, in which unmethylated CpG motifs bind to TLR9. DNA methyltransferases (DNMTs) such as DNMT1 and DNMT3A are involved in nuclea...
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King's College London (University of London)
2018
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.745392 |