Using VCP mutant hiPSC-derived motor neurons and glia to capture early molecular pathogenic events in MND

Motor neuron disease (MND) is rapidly progressive and invariably fatal, and with no significantly impactful therapies available to date there is desperate and unmet clinical need. Recent discoveries in the underlying pathology and genetics of MND suggest that altered proteostasis, RNA regulation and...

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Bibliographic Details
Main Author: Hall, C. E.
Other Authors: Ule, J. ; Patani, R. ; Wood, N.
Published: University College London (University of London) 2016
Subjects:
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746295