Proteomics Based process and cell line development applied to a mammalian therapeutic enzyme
Recombinant human Acid Alpha Glucosidase (GAA) is the therapeutic enzyme used for the treatment of Pompe disease, a rare genetic disorder characterised by GAA deficiency in the cell lysosomes. The manufacturing process for GAA can be challenging, in part due to protease degradation. The overall goal...
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University College London (University of London)
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746676 |