The role of the transcription factor Gli3 and Hedgehog signalling in fetal B cell and thymocyte development
Gli3 is a Hedgehog (Hh) responsive transcription factor that can function as a transcriptional repressor or activator. Here, we show that Gli3 is required for both fetal B cell and thymocyte development. Gli3 represses Shh in the fetal liver and thymus, hence Gli3 deficiency shows both Gli3 dependen...
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University College London (University of London)
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746796 |