Investigation of mechanisms for enhancing expression of human FVIII in vitro : application to therapeutic protein production
Haemophilia A is the most common bleeding disorder and is caused by deficiency or abnormality in coagulation Factor VIII (FVIII). Deletion of the B-domain dramatically improves secretion of this protein with no alteration of the pro-coagulant activity of the B-domainless FVIII. Previous work has sho...
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University College London (University of London)
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746846 |