Design, synthesis, and optimisation of highly selective macrocyclic CDK9 inhibitors
Cyclin dependent kinases (CDKs) belong to a family of serine/threonine protein kinases that play a key role in cell cycle and transcriptional regulation. CDK9, in complex with its regulatory partner cyclin T1, is involved in RNA transcriptional regulation through phosphorylating the RNA polymerase I...
| Main Author: | |
|---|---|
| Published: |
University of Nottingham
2018
|
| Subjects: | |
| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748363 |