Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase

Protein-protein interactions (PPIs) are prevalent in Nature and so are attractive targets for chemical biology and drug discovery. Modulating PPIs is challenging because of the nature of their interacting surfaces. Nevertheless, recent progress has led to the discovery of small molecule modulators o...

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Bibliographic Details
Main Author: Soares, Pedro
Other Authors: Ciulli, Alessio
Published: University of Dundee 2018
Subjects:
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762963