The MDMX (MDM4) oncoprotein as a therapeutic target and determinant of response to MDM2-p53 binding antagonists in human cancer
The tumour suppressor p53 is activated by cellular stress to induce cell cycle arrest and/or apoptosis. Despite being frequently mutated, theTP53 gene is wild-type and functional in approximately 50% of human cancers. Targeting the p53 tumour suppressor pathway by inhibition of its negative factors...
| Main Author: | |
|---|---|
| Published: |
University of Newcastle upon Tyne
2017
|
| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765265 |