Characterization of the structure and function of NF-KappaB essential modulator and its interaction with inhibitor of KappaB Kinase Beta and development of a screening protocol to discover and validate inhibitors of the interaction
Protein-protein interactions (PPI) mediate numerous biological processes, but inhibiting these interactions with small molecules has been difficult to achieve in drug discovery. A small number of successes have shown that some PPIs are amenable to inhibition. Computational algorithms designed to mea...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/14292 |