Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor
A large body of data exists demonstrating the key role of FcRn in extending the half-life of therapeutic antibodies by rescuing them from lysosomal degradation. This led to the widely accepted hypothesis that FcRn binding of an IgG via the CH2-CH3 interface of Fc correlates with IgG half-life. Seve...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/14377 |