Development of TDP-43 granule inhibitors as potential amyotrophic lateral sclerosis and frontotemporal lobar degeneration therapies
The 43 kDa TAR DNA binding protein (TDP-43) has been identified as one of the major proteins that accumulates in the cytoplasm of brain and spinal cord from the patients affected with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Under basal conditions, TDP-43 lo...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/14606 |