Non-canonical cell signaling actions of pregnenolone sulfate, a neurosteroid that increases intracellular calcium, activates creb phosphorylation and stimulates trafficking of NMDA receptors to the surface of neurons

Non-canonical cell signaling actions of pregnenolone sulfate, a neurosteroid that increases intracellular calcium, activates creb phosphorylation and stimulates trafficking of NMDA receptors to the surface of neurons

Preclinical results support the use of N-methyl D-aspartate receptor (NMDAR) modulators for cognition enhancement therapeutics. Pregnenolone sulfate (PregS) is a neuroactive steroid derived from cholesterol that augments long term potentiation (LTP) in hippocampal slices and improves memory performa...

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Bibliographic Details
Main Author: Smith, Conor C.
Language:en_US
Published: 2016
Subjects:
Pharmacology
CREB
NMDA receptor
Calcium
Pregnenolone sulfate
Steroid
Online Access:https://hdl.handle.net/2144/15222

Internet

https://hdl.handle.net/2144/15222

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