New approach to compare treatments in adaptive seamless designs while maintaining Type I error and ensuring adequate power
In superiority "exploratory" Phase II clinical trials, we often compare the efficacy of several doses of an experimental product versus a control group (often a placebo). We then use the results from the Phase II to design the subsequent confirmatory superiority Phase III trial, and we use...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/15700 |