Examining the association between BRCA1 and topoisomerase I in cancer cells in response to camptothecin treatment
DNA topoisomerase I (TopoI) is an essential enzyme involved in the relief of DNA supercoiling during replication. TopoI plays important role in various DNA events, however the recognition that it is the target of anticancer drug camptothecins (CPTs) led to the rapid growth in this field. CPTs inhibi...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/16005 |